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Super-sized Cisplatin molecule effective against cancer while being less toxic


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28 June 2010 Email This Post Email This Post Print This Post Print This Post

Cisplatin MoleculeUsing chemistry and nanotechnology, researchers at Harvard and Brigham and Women’s Hospital designed a super-sized Cisplatin molecule able to deliver toxic platinum atoms to tumors while proving nontoxic to kidneys.  The research was conducted on laboratory animals.

Cisplatin is a powerful anti-cancer drug used in first-line chemotherapy but with limited use because of its toxicity. The team designed a polymer what would bind to Cisplatin, making it wrap itself into a 100 nanometers ball, too large to enter the kidneys, lungs, liver and spleen.  Once the molecule reached the tumor it falls apart dumping its toxic load on the cancerous tissue.

The new compound has been found to be effective against lung and breast cancers and outperformed Cisplatin in a transgenic ovarian cancer model that mimics the disease in humans




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