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Infliximab was used in cystic fibrosis and Crohn’s disease treatment with promising results


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19 April 2010 Email This Post Email This Post Print This Post Print This Post

Infliximab PillsInfliximab, a monoclonal antibody, was used in treating a patient suffering from cystic fibrosis and Crohn’s disease with some success, according to a research published in the World Journal of Gastroenterology.  After initiation of infliximab in this patient, there was an improvement of colonic lesions and general condition without any infective complication and particularly without any decline of lung function.

Cystic fibrosis is a common hereditary disease in Caucasian children which affects the entire body, causing progressive disability and often early death with an incidence of 1 case in every 2500 children born alive.  Crohn’s disease is an inflammatory disease of the intestines which may be localized throughout the gastrointestinal tract, causing a wide variety of symptoms like abdominal pain, diarrhea, vomiting or weight loss.

This report confirms the preliminary data regarding the possibility that airway inflammation in cystic fibrosis plays a crucial role in lung damage and that the inflammation is mediated by tumor necrosis factor alpha. Therefore, the use of anti-tumor necrosis factor alpha antibody improved Crohn’s disease and did not generate any complications of lung function, perhaps promoting an anti-inflammatory effect both on colon and lung.




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