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OSU-CG12 kills cancer cells

8 April 2010 Email This Post Email This Post Print This Post Print This Post

OSU-CG12 Dr. Ching-Shih ChenOSU-CG12 , a energy-restriction mimetic agent, is an experimental anticancer drug that causes the cancer cells to self destruct by choking off the sugar supply. OSU-CG12  was designed by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

Researchers showed that OSU-CG12 is 10 time more efficient in killing cancer cells then ciglitazone or resveratrol by using breast cancer and prostate cancer cell line. Also the agent suppresses the cell’s ability to metabolize sugar and stops the glucose from entering cancer cells which leads to the cancer cells consuming themselves as well other biochemical events that eventualy lead to the cell’s death.

“Our study proves that this new agent kills cancer cells through energy restriction. This is important because it shows that it is possible to design drugs that target energy restriction, and it is exciting because energy-restricting mimetic agents may also be useful for other diseases, including metabolic syndromes, diabetes, cardiovascular disease and obesity,” said Ching-Shin Chen, principal investigator.

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